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methotrexate v leflunomide Options
heather1
#1 Posted : Friday, December 28, 2012 12:29:56 PM Quote
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Location: hampshire
Hi all, am taking 25mg per week (injection) of mx and started taking leflunomide in October. It has made a big difference (within 2 weeks) however, over the last few weeks, after taking my injection (thursday night) Ive been suffering all weekend with the most horrendous headaches and nausea. Sunday pm through to thursday Im fine so am presuming its MX. Ive spoken to the rheummy nurse today who has said to lay off mx for 2 weeks and see if this makes things better, if not, go back on it and drop the leflunomide. Am so hoping that I can come off mx as it has always made me very nauseous. Has anyone else had anything like this at all?

Love Heather xxxx
Naomi1
#2 Posted : Saturday, December 29, 2012 7:20:53 PM Quote
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Location: Torbay
Heather, I'm just wondering if you are drinking enough with the Mtx. I've been told it's essential to stay hydrated in the days after taking Mtx. It might be worth thinking about this before giving up on either of the drugs. Good luck and please let us know the outcome.
bpeal1
#3 Posted : Sunday, December 30, 2012 11:02:32 PM Quote
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Location: Shrivenham, Oxfordshire
I couldn't tolerate MXT at all. Only tried 15mg by tablet and injection and both made me feel very ill. I tried increasing folic acid too but nothing helped. I felt very sick for 5 days after taking it and also very dizzy and felt as if my head wasn't attached to my body. After discussing it with my rheumy team we decided I couldn't carry in like that so I switched.to leflunomide and have had no problems with it.

However we are all different and tolerate diffrent drugs. Hope you work out which one is causing problems for you

Becky
sylviax
#4 Posted : Monday, December 31, 2012 12:04:28 PM Quote
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Hi Heather - hope you find something that helps with the side effects. It must be very distressing for you - do you take ameprazole or something similar to protect your tummy?

Good luck - Sylvia xx
Be kinder than is necessary because everyone you meet is fighting some kind of battle
jenni_b
#5 Posted : Monday, December 31, 2012 12:20:37 PM Quote
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Location: nr Southampton
You can take leflinomide without mtx
I know
I took it thAt way

Please take care of yourself, travel sweets to suck help
Get a blood test booked too
Take care x
how to be a velvet bulldoser
heather1
#6 Posted : Monday, December 31, 2012 2:17:51 PM Quote
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Joined: 2/26/2010
Posts: 271
Location: hampshire
Hi all, many thanks for the replies. I feel much better since Friday, I really do think its the mx, so fingers crossed I'll be able to come off it and just take leflunomide which in all honesty has made a difference.

Hope you all have a happy, pain free new year!

Lots of love

Heather xxxx
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